G6PD and Jaundice: The five high-frequency mutation sites were the <i>UGT1A1</i> gene c.211G>A and c.-55_-54insAT sites, the <i>G6PD</i> gene c.1376G>T, c.871G>A, and c.1388G>A sites, and the <i>SLC10A1</i> gene c.800C>T site.<h4>Conclusion</h4>Genetic factors significantly contribute to the development of infant jaundice of unknown etiology.