Interpretability was analyzed with SHapley Additive exPlanations (SHAP).<h4>Results</h4>Multivariate analysis identified a history of diabetes, previous ear surgery, otorrhea, middle ear mucosal status, cholesteatoma presence, Eustachian tube function score, and preoperative C-reactive protein level as independent risk factors. This evidence concerns the gene CRP and cholesteatoma.