<i>In vitro</i> validation was performed using TNF-α-stimulated HFLS-RA cells, followed by RT-qPCR analysis.<h4>Results</h4>Three key genes-EPYC, MAGED1, and LAP3-were identified as overlapping features between the LASSO and SVM-RFE models. The gene discussed is EPYC; the disease is rheumatoid arthritis.