However, the LDL-C/HDL-C ratio exhibited no correlation with renal IgA deposition intensity (<i>r</i> = 0.013, <i>p</i> = 0.624).<h4>Conclusion</h4>Elevated LDL-C/HDL-C ratio constitutes an independent risk factor for end-stage renal disease (ESRD) in patients with IgA nephropathy (IgAN), demonstrating a linear dose-response relationship and serving as a reliable prognostic biomarker independent of IgA deposition. This evidence concerns the gene CD79A and chronic kidney disease.