We performed a systematic review and meta-analysis about the detection rate (DR) of [<sup>99m</sup>Tc]Tc-PSMA SPECT/CT in PCa patients.<h4>Methods</h4>A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Cochrane libraries was performed to extract relevant published articles about the DR of [<sup>99m</sup>Tc]Tc-PSMA SPECT/CT in patients affected by PCa.<h4>Results</h4>Twenty-three studies (<i>n</i> = 1,840 patients) were included in the systematic review with 19 studies eligible for the meta-analysis. This evidence concerns the gene FOLH1 and posterior cortical atrophy.