STAT3 and Dravet syndrome: <i>In vivo</i> validation confirmed p-STAT3 hyperactivation in hippocampal gliosis (<i>p</i> < 0.0001), which exhibited robust linear correlations with peripheral markers (<i>r</i> ≥ 0.94, <i>p</i> < 0.001).<h4>Conclusion</h4>This study identifies systemic and neuroinflammatory changes in DS associated with increased STAT3 signaling and this inflammatory signature is also observed in the broader pediatric DRE population.