PTK2B and Alzheimer disease: In the ADNI cohort, PTK2B expression was elevated in AD (ANOVA P = 0.0023), inversely correlated with MMSE (r = -0.164, P = 0.017), and predictive of MCI-to-AD conversion (Cox HR = 1.741, P = 0.050), with independent replication in AddNeuroMed (FDR P = 3.56 × 10<sup>-4</sup>).