TNFRSF1B and bacterial infectious disease: Cell-cell communication and pseudotime analyses further suggested that tnf-tnfrsf1b signaling and progressive upregulation of mapk6/mapk11 along myeloid lineages contribute to the early splenic antibacterial response.<h4>Conclusion</h4>This study provides a genome to single-cell view of MAPK family organization and immune function in bighead carp, and identifies mapk6 and mapk11 as potential mediators of the early spleen response to bacterial infection.