<i>Toxocara canis (T.canis)</i>, one of the most prevalent helminthic infections worldwide, has been sporadically linked to autoimmune phenomena through mechanisms such as molecular mimicry, immune complex formation, and chronic inflammation.<h4>Case report and literature review</h4>We describe a 45-year-old woman who developed histologically confirmed small-vessel vasculitis of the intestine with perforation, accompanied by cutaneous vasculitis, arthralgia, pruritus, eosinophilia, and elevated IgE and seropositivity for <i>T. This evidence concerns the gene IGHE and cutaneous vasculitis.