Here, we studied the potential use of the <i>Stat3</i> gene to induce STAT3 expression in mitochondria to help treat IBD.<h4>Methods</h4>We transferred the <i>Stat3</i> gene and examined its effects on the expression of proinflammatory cytokines and fibrosis markers, and mitochondrial function, in intestinal tissues via immunohistochemistry. This evidence concerns the gene STAT3 and inflammatory bowel disease.