SOST and diabetic kidney disease: ROC curve analysis showed that the AUC for predicting DKD using serum sclerostin and 25(OH)VD was 0.73, with a sensitivity of 61.1% and specificity of 75%.<h4>Conclusion</h4>This study confirms that serum levels of sclerostin and 25(OH)VD are significantly reduced in patients with DKD, and both are independent protective factors for DKD.