APOA1 and atherosclerosis: Its involvement extends beyond lipid transport to include anti-inflammatory and antioxidant mechanisms.<h4>Objective</h4>To comprehensively evaluate the role of ApoA-I in ASCVD, including its biological functions, clinical relevance as a biomarker, and potential as a therapeutic target.<h4>Methods</h4>A scoping review of the literature was conducted to examine current evidence on ApoA-I in cardiovascular health and disease.