The observation of these trials is a greater than 2 log decrease from baseline in hepatitis D virus ribonucleic acid (HDV RNA) in 54-92% of patients and normalization of alanine transaminase (ALT) in 48.8-74% of patients after 23-144 weeks of treatment, and a significant decrease in liver fibrosis, as quantified by Fibroscan, at 12 months of treatment. The gene discussed is GPT; the disease is Hepatic fibrosis.