Additionally, a significant (<i>p</i> < 0.001) correlation between IL-1β and hepatic injury parameters was observed.<h4>Conclusions</h4>These findings suggest a potential association between NAFLD and the IL-1β/iNOS and IL-1β/CD45 axes of liver injury and fibrosis, as well as dyslipidemia, glycemia, and apoptosis, with quercetin exhibiting beneficial hepatic pleiotropic effects. The gene discussed is NOS2; the disease is metabolic dysfunction-associated steatotic liver disease.