Mitochondrial function, oxidative stress, inflammation, and expression of mitophagy (Pink1, Park2, Bnip3, Fundc1) and thermogenic (Ucp1, Pgc1a, Prdm16, Cidea) genes were measured.<h4>Results</h4>Compared with the con group, DM mice showed obesity, hyperglycemia and blunted circadian metabolic rhythm. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.