<b>Case Presentation:</b> We report a unique case of <i>de novo</i> AML harboring two clonal, transcriptionally active class-defining fusions: <i>CBFB</i>::<i>MYH11</i> and <i>GOLGA4</i>::<i>PDGFRB</i>. This evidence concerns the gene CBFB and acute myeloid leukemia.