<b>Background:</b> Acute myeloid leukemia (AML) with <i>CBFB</i>::<i>MYH11</i> fusion and myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK) are genetically defined and typically mutually exclusive entities. Here, MYH11 is linked to acute myeloid leukemia.