Promoter methylation analysis revealed significantly increased <i>AURKAIP1</i> methylation in AML (<i>p</i> < 0.001), decreased <i>E2F4</i> methylation (<i>p</i> = 0.023), and no significant change in <i>E2F1</i>. This evidence concerns the gene AURKAIP1 and acute myeloid leukemia.