OCLN and inflammatory bowel disease: In paired biopsies (<i>n</i> = 127), TJ architecture-particularly in the CR-improved over time, with reduced expression and a shift toward membranous localization, most prominently in bio-experienced patients.<h4>Conclusions</h4>TJ remodeling, particularly crypt-level occludin dysregulation, is associated with disease activity and clinical outcomes, capturing a clinically relevant dimension of epithelial barrier dysfunction in IBD.