Mitogen-activated protein kinase kinase kinase 7 (<i>MAP3K7</i>), also known as transforming growth factor-<i>β</i>-activated kinase 1 (TAK1), is a widely expressed kinase that plays a crucial role in various cellular processes variants in the <i>MAP3K7</i> gene have been implicated in two distinct genetic disorders: frontometaphyseal dysplasia Type 2 (FMD2) and cardiofaciocutaneous syndrome (CSCF). This evidence concerns the gene MAPK7 and cardiofaciocutaneous syndrome.