The ROC analysis demonstrated that miR-577 and miR-505-3p have acceptable diagnostic values, and miR-3682-3p has a relatively proper diagnostic value in diagnosing breast cancer.<h4>Conclusion</h4>Our results revealed that miR-577 and miR-505-3p could be used as biomarkers for the diagnosis of breast cancer, especially in ER+ subtype. This evidence concerns the gene ESR1 and breast carcinoma.