The aim of this study was to assess clinical studies by use of a systematic review on some mouth biomarkers except of interleukin, active metalloproteinase (MMP) and TNF-α in peri-implantitis patients.<h4>Materials and methods</h4>A regular and complete search was conducted through mesh keywords by search of the Science Direct, PubMed, Google Scholar database until August 6, 2024. The gene discussed is TNF; the disease is Peri-Implantitis.