Therefore, the aim of this study was to compare the diagnostic performance and clinical relevance of measuring specific IgE to <i>Dermatophagoides pteronyssinus</i> and <i>Blomia tropicalis</i> extracts vs. two allergen combinations, Blo t 2/Blo t 5/Blo t 21 and Der p 1/Der p 2/Der p 23.<h4>Methods</h4>In 201 adults with asthma and matched controls, diagnostic performance of specific IgE towards molecular allergen combinations and extracts were compared using receiver operator characteristics analysis, with physician-diagnosed asthma as reference standard. Here, IGHE is linked to asthma.