Protein expression (SOD, CAT, NRF2), enzymatic activities (SOD, CAT), and oxidative damage markers (8-OHdG, MDA, NO) were assessed by immunofluorescence and/or colorimetric assays.<h4>Results</h4>MOI 1 for 24 hours produced the highest NS1 expression and infection rate (62.53%) and higher viability (89% vs. 28.1%), establishing this as the optimal condition. This evidence concerns the gene SOD1 and infection.