In terms of immune indicators, the counts of lymphocytes, total T cells and CD4+ T cells in the HBV-TB group were all lower than those in the HBV group, while the levels of IFN-γ and IL-6 were higher(all P<0.05).<h4>Conclusion</h4>It is recommended that HBsAg screening be conducted for all tuberculosis patients before anti-tuberculosis treatment, and preventive antiviral treatment be given to individuals with positive HBsAg to reduce the risk of HBV reactivation. The gene discussed is CD4; the disease is tuberculosis.