This metabolic disease, characterized by an increase in body mass index (BMI), leads to abnormal fat accumulation that contributes to several pathologies, and is determined by a complex interaction between diet, lifestyle and genetic factors, such as single nucleotide variants (SNVs) that may influence appetite regulation, adipose tissue function, energy metabolism, reward mechanisms, motivation, food intake behavior control, energy expenditure, fatty acid transport, lipid accumulation, lipolysis, insulin sensitivity, glucose metabolism, among other biochemical processes. The gene discussed is INS; the disease is metabolic disease.