<h4>Background</h4>Exposure to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may promote the initiation and progression of prostate cancer (PCa); however, its precise molecular mechanisms remain unclear.<h4>Methods</h4>By integrating network toxicology, bioinformatics, and machine learning algorithms, potential molecular targets of PhIP in PCa were identified. The gene discussed is PHIP; the disease is Familial prostate cancer.