IFIH1 and interstitial lung disease: This study aimed to identify factors influencing the occurrence of RP-ILD in patients with MDA5+ DM-ILD.<h4>Methods</h4>A systematic search was conducted in PubMed, EMBASE, the Cochrane Library, Web of Science, and Scopus for studies investigating factors associated with RP-ILD in MDA5+ DM-ILD, with the search period extending to January 1, 2026.