The results of the meta-analysis indicated that the circulating spexin in patients with T2DM was significantly lower than that of the controls (SMD: -2.32, 95% CI: -3.32, -1.31).<h4>Conclusions</h4>This meta-analysis is the first to comprehensively evaluate the level of circulating spexin in patients with T2DM. The gene discussed is SPX; the disease is type 2 diabetes mellitus.