Spearman correlation was performed to analyze the correlation between insulin resistance parameters and UACR, Logistic regression was used to analyze the risk factors of DKD, and the curve of ROC was drawn to evaluate the predictive efficacy of TyG index, TyG-BMI index and AIP index.<h4>Results</h4>There were 129 cases (72.07%) in T2DM group and 50 cases (27.93%) in DKD group. The gene discussed is AIP; the disease is Insulin resistance.