<h4>Background</h4>This study aimed to investigate the role of inflammatory cytokines IFN-γ and TGF-β in the pathophysiology of chronic sinusitis among Iraqi patients.<h4>Materials and methods</h4>A case-control study was conducted in Salah-Al-Din Governorate from March to July 2024. Here, TGFB1 is linked to chronic rhinosinusitis.