Ordered logistic regression analysis showed that AD had interaction effects on the associations between several immune indicators, including memory T4 cells (CD4 + CD45RA-/CD4+), 45RA + CD4+ T cells, naive CD4+ T cells, and the percentage of CD8 + CD38+/CD8+ T cells, and clinical symptoms such as picky eating, agitation, sleep disturbances, mood problems, and allergies. Here, CD8A is linked to Alzheimer disease.