Multivariate analysis identified high PMS2 expression [HR: 3.109 (2.019-4.786), <i>p</i> < 0.001], high Phosphorylated-Protein Kinase B (p-AKT) expression [HR: 2.201 (1.304-3.715), <i>p</i> = 0.003], Barcelona Clinic Liver Cancer (BCLC) stage [HR: 2.635 (1.156-5.992), <i>p</i> = 0.021], and poor pathological differentiation [HR: 1.729 (1.098-2.722), <i>p</i> = 0.018] as independent risk factors for poor DFS. This evidence concerns the gene AKT1 and liver cancer.