In multivariable logistic regression, insulin use (OR 2.555, p = 0.042), ischemic heart disease (OR 3.752, p = 0.016), and skin changes (OR 8.166, p < 0.001) were independently associated with DFUs.<h4>Conclusion</h4>DFU is relatively uncommon among diabetic patients attending PHCs in Bahrain. This evidence concerns the gene INS and Abnormality of the skin.