Subgroup analyses revealed that the predictive value of these markers was particularly pronounced in individuals aged≤60 years, females, non-obese individuals, and those without underlying conditions (hypertension, diabetes, cardiovascular disease).<h4>Conclusion</h4>This two-phase study identified several readily available inflammatory-metabolic composite indices (e.g., MHR, AIP, CMI) as independently associated with OSA risk; these markers demonstrate potential as adjunctive tools for assessing OSA risk. The gene discussed is AIP; the disease is cardiovascular disorder.