Receiver operating characteristic (ROC) curve was used to analyze the predictive value of age, smoking, hypertension, stent tortuosity, CYP2C19 poor metabolizer status and TEG parameters for patients with ISR.<h4>Results</h4>Of the 223 patients with complete follow-up data, 28 (12.56%) developed ISR within one year. This evidence concerns the gene CYP2C19 and Hypertension.