Further experiments demonstrated that BSN promoted apoptosis in A549 cells through modulation of the Akt/p53 signaling pathway.<h4>Discussion</h4>These findings indicate that BSN selectively target NSCLC cells and induce apoptosis via the Akt/p53 pathway, thereby exerting anti-tumor effects in A549 cells. The gene discussed is AKT1; the disease is neoplasm.