Additionally, clinical correlation analysis, nomogram development and validation, immune infiltration analysis, tumor mutation burden (TMB) analysis, gene set enrichment analysis (GSEA), drug sensitivity prediction, molecular regulatory network analysis, drug targeting analysis, and molecular docking were performed.<h4>Results</h4>Three genes--kinesin family member 4A (KIF4A), TPX2 microtubule nucleation factor (TPX2), and aurora kinase B (AURKB)-were identified as Kbhb-related prognostic genes. The gene discussed is TPX2; the disease is neoplasm.