<h4>Objective</h4>This study investigated the role of UCHL5 in thyroid carcinoma (THCA) progression, focusing on its tumor-suppressive mechanisms and regulation of ferroptosis.<h4>Methods</h4>We performed multi-omics analysis of TCGA and GEO datasets and validated the findings using clinical samples. This evidence concerns the gene UCHL5 and thyroid gland carcinoma.