The C-reactive protein-Triglyceride glucose Index (CTI), a novel composite biomarker integrating inflammatory and metabolic components, may reflect these processes, yet its association with asthma remains unclear.<h4>Methods</h4>Data from 18,579 adults in the National Health and Nutrition Examination Survey (NHANES, 1999-2010, 2015-2018) were analyzed to examine the relationship between CTI and asthma prevalence. The gene discussed is CRP; the disease is asthma.