The snRNA-seq analysis reveals endothelial MerTK dynamics in cardiac dysfunction based on specimens from human patients with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).<h4>Conclusions</h4>These findings provide compelling evidence that endothelial MerTK impairment is a novel mechanism in promoting cardiac dysfunction. Here, MERTK is linked to dilated cardiomyopathy.