The study found upregulation of several proteins in sepsis (C5, CFB, FCN3, PPBP, VWF, SAA2, ORM1, LBP) and downregulation of others (ITIH3, SERPINA4, AHSG).<h4>Conclusion</h4>These findings highlight distinct proteomic patterns between sepsis and NISIRS. The gene discussed is CFB; the disease is Sepsis.