Additionally, intracerebroventricular injection of α-syn exerted anti-seizure effects.<h4>Conclusions</h4>Our results showed that modulation of the mTOR/GLT-1 pathway ameliorated α-synucleinopathy and seizure activities in FCD, providing insights for understanding the epileptogenic mechanisms of FCD IIb and TSC. Here, SLC1A2 is linked to synucleinopathy.