Additionally, intracerebroventricular injection of α-syn exerted anti-seizure effects.<h4>Conclusions</h4>Our results showed that modulation of the mTOR/GLT-1 pathway ameliorated α-synucleinopathy and seizure activities in FCD, providing insights for understanding the epileptogenic mechanisms of FCD IIb and TSC. The gene discussed is MTOR; the disease is fleck corneal dystrophy.