Plasma membrane type-1 matrix metalloproteinase (MT1-MMP) levels (indicating vascular shear stress) were compared between groups to assess whether fast IVF boluses generate greater endothelial shearing forces than slow boluses.<h4>Methods</h4>A porcine septic shock model using lipopolysaccharide-induced endotoxemia was used. Here, MMP14 is linked to septic shock.