Cox regression analysis revealed that pT (HR = 1.826, <i>p</i> = 0.019), LY (HR = 0.318, <i>p</i> = 0.007), and tumor grade (HR = 0.505, <i>p</i> = 0.021) added to high SOX-2 and EZH-2 immunoexpression independently predicted a poor survival outcome (HR = 2.373, <i>p</i> = 0.016 and HR = 2.746, <i>p</i> = 0.015).<h4>Conclusions</h4>Our findings suggest that SOX-2 and EZH-2 may serve as biomarkers of aggressive behavior and a poor prognosis in primary epithelial MSGTs, providing potential opportunities for precision-targeted therapies. This evidence concerns the gene EZH2 and neoplasm.