MAP3K14 and chronic kidney disease: PEW was an independent predictor of impaired height velocity after adjusting for confounders (<i>β</i> = -0.32, <i>P</i> < 0.001); hs-CRP levels were positively correlated with PEW scores (<i>r</i> = 0.41, <i>P</i> < 0.001), and elevated hs-CRP (>3 mg/L) was an independent risk factor for PEW (OR = 2.86, 95% CI: 1.52-5.38, <i>P</i> = 0.001).<h4>Conclusion</h4>PEW is highly prevalent in advanced pediatric CKD, driven by inflammation and nutritional deficits, and acts as an independent predictor of growth retardation.