Spatial analysis showed nonrandom clustering of these elements, suggesting integrated response capabilities.<h4>Conclusion</h4>The regulatory architecture of the <i>Rac1</i> promoter suggests a potential molecular basis for MR-mediated resistance to ACEI/ARB therapies while simultaneously providing a predictive link to enhanced malaria susceptibility through erythrocyte remodeling pathways. Here, RAC1 is linked to malaria.