SOD1 and Renal insufficiency: In addition, oxidative stress was present as there was a significant decrease in reduced glutathione (GSH) level and superoxide dismutase (SOD) activity, and a significant increase in malondialdehyde (MDA) level.<h4>Background</h4>These findings indicate a pathogenesis cascade whereby ingestion of poorly digested food causes ruminal stasis, systemic acidosis, liver dysfunction, renal insufficiency, electrolyte disturbances, oxidative stress and oxidative stress.