The PICO strategy was followed: (1) population: healthy adult patients with AP; (2) intervention: evaluation of the levels of inflammatory biomarkers of cardiovascular disease risk (IL-6, hs-CRP, IL-1β, TNF-α, and others) before and after endodontic procedures; (3) comparison: the same patients before any endodontic intervention; and (4) outcomes: reduction in the levels of cardiovascular disease risk biomarkers.<h4>Results</h4>Twenty clinical studies were included in the qualitative analysis, and 18 reported a reduction in inflammatory biomarkers after endodontic treatment. This evidence concerns the gene IL1B and cardiovascular disorder.