The goal of this study was to compare brain activation patterns of the pan-5-HT<sub>1</sub>R agonist FPT to NLX-112, a highly selective 5-HT<sub>1A</sub>R full agonist (pEC<sub>50</sub> = 7.5) which also prevents seizures in Fmr1 knockout mice, to help establish therapeutic mechanisms in autism. This evidence concerns the gene FMR1 and autism.