Transcriptomic data of people living with HTLV-1, HAM/TSP patients and idiopathic pulmonary fibrosis patients confirm in vivo expression of the in vitro gene signature, whereas single cell RNA-seq identified a unique myeloid subset in human lung, characterized by co-expression of CCL2/ISG15/CXCL10. This evidence concerns the gene ISG15 and pulmonary fibrosis.